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| 2024-03-28 13:02:41 | onclick： | New biomimetic vesicles repair heart damage |
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Myocardial ischemia-reperfusion injury is an important challenge in cardiovascular disease, which causes the accumulation of necrotic cells and triggers an inflammatory response that damages the heart.
Recently, Rao Lang team, a researcher at Shenzhen Bay Laboratory, collaborated with Yang Yuejin team, a professor at Fuwai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, to develop a new cell membrane-bionic vesicle.The results have been published in the journal American Chemical Society-Nano and were selected for the cover paper.
The first author of the paper, Shenzhen Bay Laboratory and the University of Hong Kong jointly cultivated doctoral student Lai Jialin, said that when the patient had an emergency heart attack, the blood flow in the coronary artery would be blocked.With interventional therapy, doctors can implant stents in narrow or blocked coronary arteries to dilate blood vessels and restore blood flow, but this process can trigger ischemia-reperfusion injury, which can lead to accumulation of necrotic cells and an inflammatory response.
In response to these injuries, macrophages play a vital role in phagocytosis and preventing the accumulation of necrotic cells.However, in practical treatments, macrophage-related immunotherapies often fail, and related drug interventions can also cause serious side effects such as anemia and thrombocytopenia.In addition, reducing inflammatory response is also an important aspect of repairing damage, due to the interruption of blood supply and reperfusion, inflammatory response may occur in cardiac tissue, resulting in a series of inflammatory cascades that impair heart function.
"Among the available treatments, repairing myocardial ischemia reperfusion injury can easily trigger drug retention problems, which makes it difficult for the drug to reach the damaged part of the heart.To be able to better repair heart damage, we have developed a hybrid nano-vesicle based on genetic engineering that not only targets damaged heart sites, but also enhances macrophage-related immunotherapy and reduces inflammatory responses." said Carolyn.
According to reports, the hybrid nano vesicles based on genetic engineering are composed of three cell-derived nano vesicles from different sources. They are nano vesicles that express high affinity SIRPα variants through gene editing.
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