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2024-01-17 09:14:15 | onclick: | Viscous hydrogel may repair damaged tissue

Professor Hiroyuki Tian of the University of Chicago and collaborators have proposed that particle-releasing hydrogels can exhibit a variety of forms, including a bandage-like structure that strengthens the adhesion of damaged tissue.This biocompatible gel may provide new ways to treat ulcerative colitis, heal skin wounds, and reduce myocardial infarction.The study was published in Nature-Chemical Engineering on January 12.
Materials that repair damaged tissue need to be able to adhere closely to and adapt to irregular shapes, while also promoting cell growth.Traditional treatments, such as visible-size patches, have limited ability to adhere closely and adapt to the irregular shape of damaged tissue.Although micrograin-based materials promote tissue formation and adhesion, their application is limited by the low retention rate after delivery.
Tian and others developed a gelatin-based hydrogel that can evolve under physiological conditions similar to those in the human body to release drug-modified starch granules.These gels and human tissues create improved material interfaces both inside and outside the body.Studies have shown that the composite exhibits tissue-like properties and can take several forms, such as conventional injection gel, bandage-like configuration, bioelectric/hydrogel composite, and microneedle construction.
Animal model studies have shown that this material can effectively accelerate skin trauma repair, control symptoms of colitis induced by sodium glucan sulfate, promote heart tissue regeneration, and map heart activity using bioelectronic devices.The researchers say the material, developed from natural biological sources, could improve regenerative medicine and bioelectronic methods.This material platform can also be applied to a range of medical diagnostics and treatments in the future.

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