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| 2023-12-21 08:53:39 | onclick： | Novel nano vesicles achieve tumor immunity |
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Vaccines are currently a hot topic in the field of tumor immunotherapy.It stimulates the immune system with identified tumor antigens, thus producing a specific immune response to tumor cells, achieving tumor cell killing and preventing recurrence and metastasis.Recently, researchers Zhao Xiao and Nie Guangjun of the National Nanoscience Center proposed a "peri-vaccine" immune pre-excitation strategy using bacterial-derived nanoblasts to strengthen the immune system.
Immunoreactive strategies and tumor vaccine synergies in "perivaccine stage".Interviewee's map
"The King's Envoy" to Fight Tumors
Unfortunately, tumor patients often have significant immune system dysfunction, especially serious damage to the function of antigen-presenting cells in the natural immune system, which seriously hinders tumor vaccines from activating the immune response.
"How to intervene in the body's immune system function during the 'perivaccine period' to achieve tumor vaccine synergies is the first focus of this study."Zhao Xiao told China Science Journal that with the advancement of immunology, people's understanding of the natural immune system continues to deepen, and the researchers found that natural immune cells have a certain "memory" ability.This "memory-like effect" of the human immune system is called training immunity.
Zhao Xiao and Nie Guangjun's team have been engaged in the research of nanocarriers for tumor vaccines for a long time, and developed a variety of nanocarriers based on outer membrane vesicles (OMV).
Based on the immune training phenomenon, the team used a bacterial-derived nano-vacuum to stimulate the body to produce training immunity before OMV vaccination, thus strengthening the body's natural immune system.The immunoreactive strategy based on nano vesicle OMV can also fill the gap in the clinical application of tumor vaccine, tumor antigen prediction and vaccine preparation.
"This suggests that tumor vaccine research should not be limited to the design optimization of the vaccine itself, ignoring the impact of the body's own immune system function on tumor vaccine effectiveness."Zhao Xiao said, "Treatment should be people-oriented, tumor vaccine is 'standard' and 'subject', the patient's body is 'this' and 'jun', only 'specimen cure' and 'junchen support agent' play a role at the same time, can effectively fight tumors."“
Nanostructure-activated immunity
As a microscopic-scale nano-vesicle, how OMV affects the body's natural immune system function across scales is another focus of the study.
The team found that OMV can stimulate the body to produce high levels of inflammatory factors, especially interleukin 1β, which can enter the bone marrow, affecting multiple progenitor cell differentiation processes in hematopoietic processes.
These immune-trained antigen-presenting cells are in a high-potential state, and once exposed to tumor vaccines, they can perform antigen-presenting and adaptive immune activation functions more efficiently.
In the above process, the nanostructures of OMV play a crucial role.Nano-scale OMV can effectively deliver rich pathogen-related molecular models, especially lipopolysaccharides (LPS) to the cytoplasm of immune cells, thus activating the Caspase11-mediated nonclassical inflammatory vesicle signaling pathway.LPS, which is not nanostructured, cannot enter the cell to activate this signaling pathway.
"The study validated the above biological mechanisms using multiple transgenic mouse models, providing an important reference for nanobiology research on how nanostructures produce systemic effects."And Zhao Xiao said.
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