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from: Kaohsiung
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from: hongkong
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from: Kaohsiung
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from: taizhong
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from: Kaohsiung
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| 2023-11-06 08:57:59 | onclick： | Mystery of anemia and thrombocytopenia in tumor patients solved |
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Nature Immunology recently published an online study on blood abnormalities in cancer patients.After three years of exploration, the Huangbo team of the Institute of Basic Medicine of the Chinese Academy of Medical Sciences solved the mystery of anemia and platelet increase in cancer patients.
Anemia and thrombocytopenia are common symptoms in patients with advanced malignant tumors, which seriously affect the treatment and quality of life, and even lead to death.However, scientists have not been able to find the cause of this clinical phenomenon for years.
It is noteworthy that platelets and red blood cells are differentiated from common megakaryotic erythrocytes (MEPs).Many transcription factors are involved in the differentiation of megakaryotic erythrocytes.As a member of the transcription factor, aromatic hydrocarbon receptor (AhR) plays an important role in a variety of cells, including hematopoietic progenitor cells.Previous studies have found that aromatic hydrocarbon receptors may regulate the differentiation of megakaryotic erythrocytes."Huang Bo introduced.
In this study, the team constructed humanized mouse models, rat models with aromatics receptor knockouts, and mouse models with breast and colorectal tumors.
They found that tryptophan metabolites released by tumor cells were ingested through blood circulation by megakaryocyte progenitor cells in bone marrow and activated transcription factor aromatics receptors.Aromatic hydrocarbon receptor is a key molecule in tumor immunity.Several inhibitors of aromatic hydrocarbon receptors are currently undergoing clinical trials.
Huang Bo said the work demonstrates that ARR is a key factor in tumor-related anemia and platelet growth, and is of great theoretical and clinical significance.
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