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| 2021-04-13 03:38:02 | onclick： | Aluminum is closely related to the neuropathology of familial Alzheimer's disease |
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According to information provided by IOS press on April 9, 2021, a new study continues to support increasing evidence that aluminum is related to the pathogenesis of Alzheimer's disease (AD). Researchers at Keele University found that aluminum coexists with phosphorylated tau protein, which is an early initiator of AD. The relevant research results were published on the website of Journal of Alzheimer's disease reports on April 9, 2021 - Matthew John mold, Adam O'Farrell, Benjamin Morris, Christopher exley. Aluminum and tau in neurofibrillar tangles in family Alzheimer's disease. Journal of Alzheimer's disease reports, 2021; 5 (1): 283-294. DOI: 10.3233/ADR-210011. Published: 09 April 2021. https://content.iospress.com/articles/journal-of-alzheimers-disease-reports/adr210011
The new study, published on the website of Alzheimer's disease report, is based on two earlier published studies in the same group (including mold et al., 2020, Journal of Alzheimer's disease). New data show that aluminum coexists with phosphorylated tau protein and exists in brain neurons in the form of tangles in early-onset or familial Alzheimer's disease. "The presence of these tangles is associated with neuronal cell death, and the observation of aluminum in these tangles may highlight the role of aluminum in their formation," explains Dr. Matthew John mold, lead researcher at Birchall centre, Lennard Jones laboratories, Keele University, Staffordshire, UK
Earlier studies have highlighted the extensive co localization of aluminum and amyloid - β in the brain of familial AD. In the current study, researchers used highly selective immunolabeling methods combined with aluminum specific fluorescence microscopy. In the same cohort of Colombian familial AD donors, the phosphorylated tau protein in the tangle coexisted with aluminum was found to coexist with aluminum. "What's interesting about the role of aluminum in AD, and perhaps meaningful, is that the clear association between aluminum and tau protein is not as easily recognized as amyloid - β. In these tissues, compared with tau amyloid protein, aluminum aggregates are more than tau protein, which is mainly intracellular Professor Christopher exley, the co-author, points out.
Dr. George Perry, editor in chief of the Journal of Alzheimer's disease, commented: "for nearly half a century, the accumulation of aluminum has been related to Alzheimer's disease, but this is a detailed and specific study by doctors. Dr. Matthew John mold and Dr. Christopher exley are defining the exact molecular interaction between aluminum and other multivalent metals, which may be the key to the pathogenesis of Alzheimer's disease. "
Dr. Matthew John mold said: "new data may indicate that aluminum binding to extracellular age spots precedes intracellular tau protein aggregation. These relationships with amyloid beta and tau proteins may explain the high levels of aluminum observed in brain tissues of patients with familial AD compared with patients not diagnosed with neurodegenerative disease "Tau protein and amyloid beta protein are known to synergistically produce ad neurotoxicity, and our data provide new evidence for the role of aluminum in this process." The above introduction is for reference only. Please pay attention to the original text or related reports for more information.
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